{"id":1593,"date":"2020-02-19T11:44:33","date_gmt":"2020-02-19T10:44:33","guid":{"rendered":"https:\/\/www.federicovotadesign.it\/nobilbio\/?p=1593"},"modified":"2025-07-28T17:37:44","modified_gmt":"2025-07-28T15:37:44","slug":"polyphenols-from-grape-pomace-induce-osteogenic-differentiation-in-mesenchymal-stem-cells","status":"publish","type":"post","link":"https:\/\/www.federicovotadesign.it\/nobilbio\/polyphenols-from-grape-pomace-induce-osteogenic-differentiation-in-mesenchymal-stem-cells\/","title":{"rendered":"Polyphenols from grape pomace induce osteogenic differentiation in mesenchymal stem cells"},"content":{"rendered":"<p><strong>Abstract:<\/strong> Polyphenols are increasingly investigated for the treatment of periodontitis and research on their use in dental biomaterials is currently being conducted. Grape pomace extracts are a rich source of polyphenols. In the present study, the polyphenols of two different types of grape pomace were characterized and identified by high\u2011performance liquid chromatography\u2011diode array detector, and the effect of polyphenol\u2011rich grape pomace extracts on mesenchymal stem cell (MSC) osteogenic differentiation was investigated.<br \/>\nSolid\u2011liquid extraction was used to recover polyphenols from red and white grape pomace. The two extracts have been characterized through the phenolic content and antioxidant power. Human MSCs (hMSCs) from the bone marrow were cultured both with and without given amounts (10 or 20 \u03bcg\/ml) of the obtained pomace extracts. Their effects on cell differentiation were evaluated by reverse transcription\u2011quantitative polymerase chain reaction, compared with relevant controls.<br \/>\nResults showed that both pomace extracts, albeit different in phenolic composition and concentration, induced multiple effects on hMSC gene expression, such as a decreased receptor activator of nuclear factor \u03ba\u2011\u0392 ligand\/osteoprotegerin ratio and an enhanced expression of genes involved in osteoblast differentiation, thus suggesting a shift of hMSCs towards osteoblast differentiation. The obtained results provided data in favor of the exploitation of polyphenol properties from grape pomace extracts as complementary active molecules for dental materials and devices for bone regeneration in periodontal defects.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-content\/uploads\/2025\/07\/ijmm_Polyphenols-2020.pdf\" target=\"_blank\" rel=\"noopener\">SCARICA LA PUBBLICAZIONE COMPLETA<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: Polyphenols are increasingly investigated for the treatment of periodontitis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1594,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-1593","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pubblicazioni"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/posts\/1593","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/comments?post=1593"}],"version-history":[{"count":2,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/posts\/1593\/revisions"}],"predecessor-version":[{"id":1711,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/posts\/1593\/revisions\/1711"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/media\/1594"}],"wp:attachment":[{"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/media?parent=1593"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/categories?post=1593"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/tags?post=1593"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}