{"id":1646,"date":"2022-09-07T12:44:00","date_gmt":"2022-09-07T10:44:00","guid":{"rendered":"https:\/\/www.federicovotadesign.it\/nobilbio\/?p=1646"},"modified":"2025-07-24T12:46:23","modified_gmt":"2025-07-24T10:46:23","slug":"mesoporous-bioactive-glasses-incorporated-into-an-injectable-thermosensitive-hydrogel-for-sustained-co-release-of-sr2-ions-and-n-acetylcysteine","status":"publish","type":"post","link":"https:\/\/www.federicovotadesign.it\/nobilbio\/mesoporous-bioactive-glasses-incorporated-into-an-injectable-thermosensitive-hydrogel-for-sustained-co-release-of-sr2-ions-and-n-acetylcysteine\/","title":{"rendered":"Mesoporous Bioactive Glasses Incorporated into an Injectable Thermosensitive Hydrogel for Sustained Co-Release of Sr2+ Ions and N-Acetylcysteine"},"content":{"rendered":"<p><strong>Abstract:<\/strong> An injectable delivery platform for promoting delayed bone healing has been developed by combining a thermosensitive polyurethane-based hydrogel with strontium-substituted mesoporous bioactive glasses (MBG_Sr) for the long-term and localized co-delivery of pro-osteogenic Sr2+ ions and an osteogenesis-enhancing molecule, N-Acetylcysteine (NAC). The incorporation of MBG_Sr microparticles, with a final concentration of 20 mg\/mL, did not alter the overall properties of the thermosensitive hydrogel, in terms of sol-to-gel transition at a physiological-like temperature, gelation time, injectability and stability in aqueous environment at 37 \u000eC. In particular, the hydrogel formulations (15% w\/v polymer concentration) showed fast gelation in physiological conditions (1 mL underwent complete sol-to-gel transition within 3\u20135 min at 37 \u000eC) and injectability in a wide range of temperatures (5\u201337 \u000eC) through different needles (inner diameter in the range 0.4\u20131.6 mm).<br \/>\nIn addition, the MBG_Sr embedded into the hydrogel retained their full biocompatibility, and the released concentration of Sr2+ ions were effective in promoting the overexpression of pro-osteogenic genes from SAOS2 osteoblast-like cells. Finally, when incorporated into the hydrogel, the MBG_Sr loaded with NAC maintained their release properties, showing a sustained ion\/drug co-delivery along 7 days, at variance with the MBG particles as such, showing a strong burst release in the first hours of soaking.<\/p>\n<p><strong>Keywords:<\/strong> mesoporous bioactive glasses; injectable hydrogels; N-acetylcysteine; strontium ions; co-release; delayed bone regeneration<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-content\/uploads\/2025\/07\/pharmaceutics-14-01890.pdf\" target=\"_blank\" rel=\"noopener\">SCARICA LA PUBBLICAZIONE COMPLETA<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: An injectable delivery platform for promoting delayed bone healing [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1648,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-1646","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pubblicazioni"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/posts\/1646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/comments?post=1646"}],"version-history":[{"count":1,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/posts\/1646\/revisions"}],"predecessor-version":[{"id":1649,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/posts\/1646\/revisions\/1649"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/media\/1648"}],"wp:attachment":[{"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/media?parent=1646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/categories?post=1646"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.federicovotadesign.it\/nobilbio\/wp-json\/wp\/v2\/tags?post=1646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}